What happens to the rate of transcription as the sequence approaches its consensus sequence?

As the sequence approaches its consensus sequence, the rate of transcription typically increases. The consensus sequence represents the most common or idealized sequence at a particular regulatory region of a gene, often found in promoter regions. When RNA polymerase and transcription factors encounter a sequence that closely matches this consensus pattern, the binding affinity increases, leading to more effective initiation of transcription.

This heightened interaction facilitates a stronger recruitment of the transcription machinery, ultimately enhancing the efficiency of transcription initiation. Therefore, as the sequence aligns more closely with the consensus, the transcription rate rises, due to improved accessibility and binding of necessary proteins that promote transcription.