Which GTF is known for its interaction with the promoter element during transcription initiation?

The correct choice is TFIID, which is a vital general transcription factor (GTF) in the process of transcription initiation in eukaryotic cells. TFIID is primarily known for its interaction with the TATA box, a common promoter element found in the core promoter region of many genes. This interaction is critical as TFIID acts as a scaffold for the assembly of the transcription pre-initiation complex.

TFIID is composed of several TBP-associated factors (TAFs) in addition to the TATA-binding protein (TBP). Upon binding to the promoter, TFIID promotes the recruitment of other general transcription factors and RNA polymerase II to form the complete transcription machinery necessary for the initiation of transcription.

Without the proper functioning of TFIID, the transcription initiation process would be significantly impaired, highlighting its crucial role in regulating gene expression. The other general transcription factors mentioned have distinct roles in the transcription process but do not primarily interact with the promoter in the same foundational manner as TFIID.